The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases

Article ID	Journal	Published Year	Pages	File Type
8478943	Neurochemistry International	2018	33 Pages	PDF

Abstract

Neuroprotection by sHsps (small heat shock proteins).142

Keywords

TNF AxD LPS sHSPs SBMA EAE GFAP α-Syn Hsp ERK Aβ MAPK NFκB ROS α-synuclein α-Crystallins experimental autoimmune encephalomyelitis amyotrophic lateral sclerosis Alzheimer's disease ALS Huntington's disease Neurodegenerative diseases Parkinson's disease Gene regulation intraperitoneal CNS SOD Superoxide dismutase central nervous system tumor necrosis factor nuclear factor kappa B TRAIL lipopolysaccharide TNF-related apoptosis-inducing ligand Neuroprotection Multiple sclerosis Spinocerebellar Ataxia Type 3 Nitric oxide Glial fibrillary acidic protein Heat shock protein Small heat shock proteins mitogen-activated protein kinase β-amyloid peptides extracellular regulated kinase Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology

The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases

Authors

Zhihui Zhu, Georg Reiser,