| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8479143 | Neurochemistry International | 2015 | 9 Pages |
Abstract
- (-)-Sesamin protected 6-0HDA-induced cytotoxicity via transient ERKl/2 activation.
- (-)-Sesarnin inhibited sustained ERK-p38MAPK-JNK1/2-caspase-3 system in PC12 cells.
- (-)-Sesanlin showed the prophylactic effects in 6-0HDA-Iesioned rat model of PD.
- (-)-Sesamin may serve as an adjuvant phytonutrientin PD.
Keywords
pKacyclic AMP-dependent protein kinase Ap38MAPKDOPAC6-Hydroxydopamine6-OHDA3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide3,4-dihydroxyphenylacetic acidc-Jun N-terminal kinaseERK1/2JNK1/2l-3,4-dihydroxyphenylalaninel-DOPAMTTROSParkinson's diseasetyrosine hydroxylasePC12 cellsp38 mitogen-activated protein kinaseHVAextracellular signal-regulated kinaseReactive oxygen species
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Authors
Hyun Jin Park, Ting Ting Zhao, Kyung Sook Lee, Seung Ho Lee, Keon Sung Shin, Keun Hong Park, Hyun Sook Choi, Myung Koo Lee,