| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8479302 | Neurochemistry International | 2012 | 8 Pages |
Abstract
⺠We identified NGF-regulated miRNAs in PC12 cells by microarray analysis. ⺠miR-221 overexpression induced and enhanced neuronal differentiation. ⺠Knockdown of miR-221 attenuated NGF-induced neuronal differentiation. ⺠miR-221 overexpression decreased protein expression of Foxo3a and Apaf-1. ⺠miR-221 is involved in neuronal differentiation and protection against apoptosis.
Keywords
DMEMkinase suppressor of RasMicroRNA microarrayKSRAPAf-1FOXO3aNGFGEOFBS3′-UTR3′-untranslated regionMAPKmiR-221Alzheimer’s diseasesNeuronal differentiationforkhead box O3ahorse serumfetal bovine serumPC12 cellsnerve growth factorDulbecco’s modified eagle’s mediumMicroRNAMiRNAmitogen-activated protein kinaseGene Expression Omnibus
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Authors
Nanako Hamada, Yasunori Fujita, Toshio Kojima, Aya Kitamoto, Yukihiro Akao, Yoshinori Nozawa, Masafumi Ito,