Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8479485 | Seminars in Cell & Developmental Biology | 2018 | 13 Pages |
Abstract
Since the first identification of the Scribble polarity module proteins as a new class of tumour suppressors that regulate both cell polarity and proliferation, an increasing amount of evidence has uncovered a broader role for Scribble, Dlg and Lgl in the control of fundamental cellular functions and their signalling pathways. Here, we review these findings as well as discuss more specifically the role of the Scribble module in PCP signalling.
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Authors
Michal Milgrom-Hoffman, Patrick O. Humbert,