| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8480142 | Seminars in Cell & Developmental Biology | 2016 | 28 Pages |
Abstract
Malignant Peripheral Nerve Sheath Tumours (MPNSTs) can develop from benign neurofibromas and are the main cause of death amongst NF1 patients. Through recent research on MPNSTs, we have gained insight into the key molecular events that drive their malignancy. Advances regarding malignant drivers involved in cell migration, cell invasion and angiogenic signalling are discussed in this review, where these findings will likely influence future therapies for both NF1 and related sporadic cancers.
Keywords
TKICRMP-2NF1FTiHIFMPNSTmTORC1TP53RB1OPNVEGFRCAPRIGEFPRC2Tumour protein p53LIMKRHEBCollapsin response mediator protein-2STAT3MMPpKaGRdERKCTDGTPase Activating ProteinMAPKRTKsloss of heterozygosityOsteopontinmalignant peripheral nerve sheath tumourC-terminal domainmicroRNAsCancerTumour suppressorGAPguanine nucleotide exchange factorHypoxia Inducible Factorphosphatase and tensin homologLOHmatrix metalloproteinasesignal transducer and activator of transcription 3MEKTyrosine kinase inhibitorfarnesyltransferase inhibitorMiRNAneurofibromatosis type 1Neurofibrominmechanistic target of rapamycin complex 1Pleckstrin Homologymitogen-activated protein kinasecAMP-dependent protein kinasemitogen-activated protein kinase kinasepolycomb repressive complex 2Ptenextracellular signal-regulated kinasereceptor tyrosine kinasesvascular endothelial growth factor receptorRock
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Authors
Ellie Rad, Andrew R. Tee,