Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8480277 | Seminars in Cell & Developmental Biology | 2015 | 9 Pages |
Abstract
Wnt/Ã-catenin signalling is a widespread cell signalling pathway with multiple roles during vertebrate development. In mouse embryonic stem (mES) cells, there is a dual role for Ã-catenin: it promotes differentiation when activated as part of the Wnt/Ã-catenin signalling pathway, and promotes stable pluripotency independently of signalling. Although mES cells resemble the preimplantation epiblast progenitors, the first requirement for Wnt/Ã-catenin signalling during mouse development has been reported at implantation [1], [2]. The relationship between Ã-catenin and pluripotency and that of mES cells with epiblast progenitors suggests that Ã-catenin might have a functional role during preimplantation development. Here we summarize the expression and function of Wnt/Ã-catenin signalling elements during the early stages of mouse development and consider the reasons why the requirement in ES cells do not reflect the embryo.
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Authors
Silvia Muñoz-Descalzo, Anna-Katerina Hadjantonakis, Alfonso Martinez Arias,