Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8480596 | Seminars in Cell & Developmental Biology | 2014 | 7 Pages |
Abstract
The single-strand-RNA binding protein KSRP is able to negatively regulate gene expression operating with at least two distinct and integrated postranscriptional mechanisms: (i) by promoting decay of unstable mRNAs and (ii) by favoring maturation from precursors of select microRNAs (miRNAs) including the prototypical tumor suppressor let-7. Studies performed in primary and cultured cells as well as in mice proved that the ability of KSRP to integrate different levels of gene expression is required for proper immune response, lipid metabolism, cell-fate decisions, tissue regeneration, and DNA damage response.
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Authors
Roberto Gherzi, Ching-Yi Chen, Andres Ramos, Paola Briata,