Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8480647 | Seminars in Cell & Developmental Biology | 2014 | 12 Pages |
Abstract
Obesity and diabetes represent key healthcare challenges of our day, affecting upwards of one billion people worldwide. These individuals are at higher risk for cancer, stroke, blindness, heart and cardiovascular disease, and to date, have no effective long-term treatment options available. Recent and accumulating evidence has implicated the developmental morphogen Hedgehog and its downstream signalling in metabolic control. Generally thought to be quiescent in adults, Hedgehog is associated with several human cancers, and as such, has already emerged as a therapeutic target in oncology. Here, we attempt to give a comprehensive overview of the key signalling events associated with both canonical and non-canonical Hedgehog signalling, and highlight the increasingly complex regulatory modalities that appear to link Hedgehog and control metabolism. We highlight these key findings and discuss their impact for therapeutic development, cancer and metabolic disease.
Keywords
HIF1αVLDLBOCIHHDHHSMOBCL10SAGsmoothened agonistLRP2AMPKGRK2MALT1PDHA1GAS1CaMKK2PKM2AMP-dependent kinaseCARMA1pyruvate kinase M2 isoformCK1PTXLKB1RhoANF-kBPPARγSufuGSK3βpKaRac1Igf1Desert HedgehogIndian HedgehogShhDevelopmentRas-related C3 botulinum toxin substrate 1Cancersuppressor of fusedpertussis toxinSmoothenedsonic hedgehoghypoxia-inducible factor 1αinsulin-like growth factor 1nuclear factor kappa-light-chain-enhancer of activated B cellsvery low-density lipoproteinMetabolismCDOprotein kinase APtchPatchedcasein kinase 1liver kinase B1Peroxisome proliferator-activated receptor gammaGlycogen synthase kinase 3β
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Authors
Raffaele Teperino, Fritz Aberger, Harald Esterbauer, Natalia Riobo, John Andrew Pospisilik,