Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8480693 | Seminars in Cell & Developmental Biology | 2014 | 9 Pages |
Abstract
Lipids play an essential role in the structure of the endosomal membranes as well as in their dynamic rearrangement during the transport of internalized cargoes along the endocytic pathway. In this review, we discuss the function of endosomal lipids mainly in mammalian cells, focusing on two well-known components of the lipid rafts, sphingomyelin and cholesterol, as well as on three anionic phospholipids, phosphatidylserine, polyphosphoinositides and the atypical phospholipid, bis(monoacylglycero)phosphate/lysobisphosphatidic acid. We detail the structure, metabolism, distribution and role of these lipids in the endosome system as well as their importance in pathological conditions where modification of the endosomal membrane flow can lead to various diseases such as lipid-storage diseases, myopathies and neuropathies.
Keywords
CHOLPolyphosphoinositidesPtdIns(3)PPtdInsPPtdIns(3,5)P2PtdEthPtdInsGPLPtdSerTGNNCLGPiMAMLSDAPsneuronal ceroid lipofuscinosisPtdIns(4,5)P2Endocytosissphingomyelinpolyunsaturated fatty acid(s)PUFAanti-phospholipid syndromeTrans-Golgi networkendoplasmic reticulumCADPlasma membranephosphatidylinositolphosphatidylcholinephosphatidylglycerolphosphatidylethanolaminePhosphatidylserinephosphatidylinositol 3-phosphatePhosphatidylinositol 3,5-bisphosphatephosphatidylinositol 4,5-bisphosphatephospholipid(s)LDLPleckstrin HomologyCardiolipincholesterolglycosylphosphatidylinositol
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Authors
Françoise Hullin-Matsuda, Tomohiko Taguchi, Peter Greimel, Toshihide Kobayashi,