Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8485586 | Vaccine | 2018 | 6 Pages |
Abstract
The results show that C. abortus vaccine strain 1B has an identical genome sequence to the non-attenuated “reverted mutant” strain 1H. Thus, the protection of the 1B vaccine is unlikely to be due to the NTG induced SNPs and is more likely caused by the administration of high doses of C. abortus elementary bodies that stimulate protective immunity. Vaccine-identical strains were also isolated from cases of disease, as well as strains which had acquired 1-3 SNPs, including an animal that had not been vaccinated with either of the commercial live OEA vaccines, indicating that the 1B vaccine strain may be circulating and causing disease.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
David Longbottom, Michelle Sait, Morag Livingstone, Karine Laroucau, Konrad Sachse, Simon R. Harris, Nicholas R. Thomson, Helena M.B. Seth-Smith,