| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8485722 | Vaccine | 2018 | 10 Pages |
Abstract
In conclusion, based on evidence to our finding, nasal vaccination with r4M2e.HSP70c antigen encapsulated into N-Trimethyl Chitosan (TMC) nanoparticulate system showed to induce a long lasting M2e-specific humoral and cellular immune responses and also provided full protection against a 90% lethal dose (LD90) of the influenza virus A/PR/8/34 (H1N1). It seems, protective immunity following intranasal administration of r4M2e could be resulted by the cooperation of both adjuvants, TMC and HSP70c.
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Authors
Mehran Dabaghian, Ali Mohammad Latifi, Majid Tebianian, Hamid NajmiNejad, Seyyed Mahmoud Ebrahimi,