Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8486490 | Vaccine | 2017 | 8 Pages |
Abstract
Our data show that cyclic di-adenosine monophosphate (c-di-AMP) and archaeosomes elicit strong neutralizing antibodies similar to those elicited using aluminum hydroxide/monophosphoryl lipid A (Alum/monophos. /MPLA) and MF59. However, both c-di-AMP and archaeosomes induced a more robust cellular immune response, which was confirmed by the detection of vaccine-specific poly-functional CD4+ T cells. We conclude that these adjuvants may substantially boost the immunogenicity of our E1E2 vaccine. In addition, our data also indicates that use of a partial or exclusive intranasal immunization regimen may also be feasible using c-di-AMP as adjuvant.
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Immunology
Authors
A. Landi, J. Law, D. Hockman, M. Logan, K. Crawford, C. Chen, J. Kundu, T. Ebensen, C.A. Guzman, L. Deschatelets, L. Krishnan, D.L.J. Tyrrell, M. Houghton,