| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8486736 | Vaccine | 2012 | 9 Pages |
Abstract
⺠A polyepitope TB vaccine was designed from five HLA-DR3-restricted T-cell epitopes. ⺠Epitopes are derived from Mtb proteins expressed by replicating and dormant bacilli. ⺠Polyepitope immunization of HLA-DR3 mice induced immunity against Mtb. ⺠Polyepitope immunization reduced CFU in lungs of HLA-DR3 mice after live Mtb challenge.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Annemieke Geluk, Susan J.F. van den Eeden, Krista E. van Meijgaarden, Karin Dijkman, Kees L.M.C. Franken, Tom H.M. Ottenhoff,