Article ID Journal Published Year Pages File Type
8486744 Vaccine 2012 6 Pages PDF
Abstract
► We determined how nanoparticle size modulates mucosal immunity in mice. ► Two sizes 200 and 30 nm nanoparticles were compared after intranasal immunization. ► 200 nm nanoparticles enhanced lung antigen-specific CD4+ T cell immunity. ► 200 nm nanoparticles increased IFNγ production by CD4+ T cells on a per-cell basis. ► 200 nm nanoparticles increased both systemic and mucosal antibody responses.
Related Topics
Life Sciences Immunology and Microbiology Immunology
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