Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8497615 | Developmental & Comparative Immunology | 2018 | 10 Pages |
Abstract
LPS is a common component of the outermost cell wall in Gram-negative bacteria. For mammals, LPS serves as an endotoxin to induce a strong immune response. In Drosophila melanogaster, no receptors for LPS have been identified and LPS can't activate immune responses. In this paper, we report a protein, BmEsr16, which contains an ML domain, may function as a receptor for LPS in the silkworm. Our results showed that LPS-induced immune responses in the hemolymph of B. mori larvae were blocked when endogenous BmEsr16 protein was neutralized by polyclonal antibody specific to BmEsr16.192
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Authors
Ruo-Nan Zhang, Fei-fei Ren, Cheng-Bo Zhou, Jun-Feng Xu, Hui-Yu Yi, Ming-Qiang Ye, Xiao-Juan Deng, Yang Cao, Xiao-Qiang Yu, Wan-Ying Yang,