Article ID Journal Published Year Pages File Type
8497615 Developmental & Comparative Immunology 2018 10 Pages PDF
Abstract
LPS is a common component of the outermost cell wall in Gram-negative bacteria. For mammals, LPS serves as an endotoxin to induce a strong immune response. In Drosophila melanogaster, no receptors for LPS have been identified and LPS can't activate immune responses. In this paper, we report a protein, BmEsr16, which contains an ML domain, may function as a receptor for LPS in the silkworm. Our results showed that LPS-induced immune responses in the hemolymph of B. mori larvae were blocked when endogenous BmEsr16 protein was neutralized by polyclonal antibody specific to BmEsr16.192
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