| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8497785 | Developmental & Comparative Immunology | 2018 | 10 Pages |
Abstract
With increasing age, cotton rats showed reduced frequencies of T cells, impaired induction of antibodies to RSV, higher incidence of aberrations of organs and signs of lipemia. Moreover, old animals expressed high biological heterogeneity, but the age-related reduction of T cell frequency was only observed in those specimens that displayed aberrant organs. Thus, cotton rats show age-related alterations of lymphocytes that can be classified by links with health status.
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Authors
Teun Guichelaar, Elisabeth A. van Erp, Jeroen Hoeboer, Noortje A.M. Smits, Cécile A.C.M. van Els, Daan K.J. Pieren, Willem Luytjes,