| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8500247 | International Journal for Parasitology | 2013 | 9 Pages |
Abstract
⺠Within hours of infection, Fasciola hepatica suppresses host protective immune responses. ⺠Administration of Fasciola excretory/secretory products mimics the immune modulatory properties of live infection. ⺠Fasciola excretory/secretory products prevent the development of type 1 diabetes in mice. ⺠Cathepsin L1 secreted by F. hepatica prevents the activation of pro-inflammatory macrophages. ⺠Fasciola hepatica peroxiredoxin converts macrophages to an M2 phenotype. ⺠Fasciola helminth defence molecule-1 inhibits the processing and presentation of antigen by macrophages.
Related Topics
Life Sciences
Immunology and Microbiology
Parasitology
Authors
Mark W. Robinson, John P. Dalton, Bronwyn A. O'Brien, Sheila Donnelly,