Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8516263 | Neuropharmacology | 2018 | 40 Pages |
Abstract
Previous research shows Ouabain (OUA) to bind Na, K-ATPase, thereby triggering a number of signaling pathways, including the transcription factors NFá´B and CREB. These transcription factors play a key role in the regulation of BDNF and WNT-β-catenin signaling cascades, which are involved in neuroprotection and memory regulation. This study investigated the effects of OUA (10â¯nM) in the modulation of the principal signaling pathways involved in morphological plasticity and memory formation in the hippocampus of adult rats. The results show intrahippocampal injection of OUA 10â¯nM to activate the Wnt/β-Catenin signaling pathway and to increase CREB/BDNF and NFá´B levels. These effects contribute to important changes in the cellular microenvironment, resulting in enhanced levels of dendritic branching in hippocampal neurons, in association with an improvement in spatial reference memory and the inhibition of long-term memory extinction.
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Ana Maria Orellana, Jacqueline Alves Leite, Paula Fernanda Kinoshita, Andrea Rodrigues Vasconcelos, Diana Zukas Andreotti, Larissa de Sá Lima, Gilberto Fernando Xavier, Elisa Mitiko Kawamoto, Cristoforo Scavone,