Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8516429 | Neuropharmacology | 2018 | 36 Pages |
Abstract
As observed for PCP, ketamine markedly inhibited the activity of RtN neurons. However, unlike PCP, this effect did not translate into a disinhibition of MD/CM and mPFC excitatory neurons, possibly due to a more potent and simultaneous blockade of NMDA-Rs by ketamine in MD/CM and mPFC neurons. Hence, the present in vivo results show that ketamine evokes an early transient inhibition of neuronal discharge in thalamo-cortical networks, following its rapid pharmacokinetics, which is likely associated to its psychotomimetic effects. The prolonged increase in gamma oscillations may underlie its antidepressant action.
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Authors
Maria Amat-Foraster, Anders A. Jensen, Niels Plath, Kjartan F. Herrik, Pau Celada, Francesc Artigas,