Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C

Article ID	Journal	Published Year	Pages	File Type
8516850	Neuropharmacology	2018	9 Pages	PDF

Keywords

(PC)(tPA)(WT)(NMDA)(FDA)Activated protein C (APC)N-methyl-d-aspartate (CNS)Neurorestoration ras homolog gene family, member A large vessel occlusion General anesthesia Thrombolysis Thrombomodulin Thrombin Ras-related C3 botulinum toxin substrate 1 Food and Drug Administration Neural stem cell Neural progenitor cells Stroke acute ischemic stroke Stroke Therapy Academic Industry Roundtable central nervous system nuclear factor kappa-light-chain-enhancer of activated B cells tissue plasminogen activator intravenous tissue plasminogen activator Matrix metalloproteinase-9 Blood-brain barrier Neuroprotection subventricular zone serine protease inhibitors wild-type neurovascular unit Protein C Activated protein C protein kinase B extracellular signal-regulated kinase 1/2 endothelial protein C receptor

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Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C

Authors

Arun Paul Amar, Abhay P. Sagare, Zhen Zhao, Yaoming Wang, Amy R. Nelson, John H. Griffin, Berislav V. Zlokovic,