Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation

Article ID	Journal	Published Year	Pages	File Type
8517726	Neuropharmacology	2016	59 Pages	PDF

Keywords

NGF Tropomyosin related kinase DHEA STD NMR PC12 trkA NT-3 MβCD HEK293 CYP17 dehydroepiandrosterone SCG Jnk DRG ECD GAPDH ERK BDNF c-Jun N-terminal kinase Adiol Neuronal apoptosis Steroid Cho Alzheimer's disease Trk Neurodegeneration intraperitoneal extracellular domain Molecular dynamics human embryonic kidney cell line 293 nerve growth factor Nerve growth factor (NGF)Brain-derived neurotrophic factor Molecular modeling Neurotrophins neurotrophin-3 Chinese Hamster Ovary cell line extracellular signal-regulated kinase dorsal root ganglia Superior cervical ganglia glyceraldehyde-3-phosphate dehydrogenase

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Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation

Authors

Iosif Pediaditakis, Paschalis Efstathopoulos, Kyriakos C. Prousis, Maria Zervou, Juan Carlos Arévalo, Vasileia I. Alexaki, Vassiliki Nikoletopoulou, Efthymia Karagianni, Constantinos Potamitis, Nektarios Tavernarakis, Triantafyllos Chavakis,