Pharmacokinetic-pharmacodynamic modeling to study the anti-dysmenorrhea effect of Guizhi Fuling capsule on primary dysmenorrhea rats

Article ID	Journal	Published Year	Pages	File Type
8517833	Phytomedicine	2018	39 Pages	PDF

Keywords

NTG β-EP PK-PD PTG AUC0-t PDM PGF2α TXB2 Emax PGS tmax OCs PGE2 TCM ALB NSAIDS Cmax COX LLOQ 6-keto-PGF1α 6-keto-prostaglandin F1α CL/F Prunasin t1/2 β-endorphin albiflorin amygdalin cyclooxygenase maximal effect internal standard Arachidonic acid Cinnamic acid AMY thromboxane B2 apparent volume of distribution lower limit of quantification Nonsteroidal anti-inflammatory drugs traditional Chinese medicines ARA Primary dysmenorrhea TCP PdG Clearance rate Prostaglandin E2 Prostaglandin F2α Prostaglandins oral contraceptives Quality-control Gallic acid

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Pharmacokinetic-pharmacodynamic modeling to study the anti-dysmenorrhea effect of Guizhi Fuling capsule on primary dysmenorrhea rats

Authors

Yezhe Cheng, Yanjie Chu, Xitong Su, Kexia Zhang, Yu Zhang, Zhenzhong Wang, Wei Xiao, Longshan Zhao, Xiaohui Chen,