| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8517852 | Phytomedicine | 2018 | 33 Pages |
Abstract
Betulin (1), mundulea lactone (2), seputhecarpan A (3), seputheisoflavone (4) and epunctanone (5) had cytotoxic effects on a panel of 9 cancer cell lines with IC50 values below 70 µM. Compound 5 had the best activity and induced apoptosis in CCRF-CEM leukemia cells through alteration of MMP and increase in ROS production. Compound 5 also induced ferroptotic cell death.66
Keywords
ABCIC50BcrpFITCMDRMMPJC-1P-gpH2DCFH-DAEGFR50% inhibitory concentration5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodideDMSOP-glycoproteinROSBenzophenoneApoptosisDimethylsulfoxideCytotoxicityFerroptosisPhytochemicalsMulti-drug resistanceMultidrug resistanceMitochondrial membrane potentialbreast cancer resistance proteinPropidium iodideATP-binding cassetteReactive oxygen speciesEpidermal growth factor receptor
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Authors
Armelle T. Mbaveng, Ghislain W. Fotso, Dominique Ngnintedo, Victor Kuete, Bonaventure T. Ngadjui, Felix Keumedjio, Kerstin Andrae-Marobela, Thomas Efferth,