Xanthone-rich extract from Gentiana dinarica transformed roots and its active component norswertianin induce autophagy and ROS-dependent differentiation of human glioblastoma cell line

Article ID	Journal	Published Year	Pages	File Type
8517928	Phytomedicine	2018	22 Pages	PDF

Keywords

AMPK β-tub LysoTracker Red TMZ LTR DHR NOR DCFDA PTX ATG GBM BAF ERK mTOR NAC PI3K GFAP 2′,7′-dichlorofluorescein diacetate 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide AMP-activated protein kinase DMSO MAPK MTT N-acetylcysteine Small interfering RNA siRNA Xanthone Acridine orange Autophagy bafilomycin A1 Crystal violet Cell differentiation Temozolomide dihydrorhodamine 123 dihydroethidium Dimethyl sulfoxide phosphoinositide 3-kinase mammalian target of rapamycin DHE Vitamin E Paclitaxel Glial fibrillary acidic protein Autophagy-related proteins mitogen-activated protein kinase Propidium iodide Chloroquine extracellular signal-regulated kinase Glioblastoma multiforme Glioblastoma

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Xanthone-rich extract from Gentiana dinarica transformed roots and its active component norswertianin induce autophagy and ROS-dependent differentiation of human glioblastoma cell line

Authors

Gordana Tovilovic-Kovacevic, Dijana Krstic-Milosevic, Branka Vinterhalter, Mina Toljic, Vladimir Perovic, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic, Nevena Zogovic,