Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8518337 | Phytomedicine | 2018 | 32 Pages |
Abstract
Naturally occuring oleanane-type tritepene saponin, ardisiacrispin B displayed significant cytotoxic effects in the 9 tested cancer cell lines with IC50 values below 10 µM. The IC50 values ranges were 1.20 µM (towards leukemia CCRF-CEM cells) to 6.76 µM [against heptocarcinoma HepG2 cells]. This compound induced apoptosis in CCRF-CEM cells via activation of inititator caspases 8 and 9 and effector caspase 3/7, alteration of MMP and increase in ROS production. Ferroptosis also contributed to its cytotoxicity.81
Keywords
DcfH2DCFP-gpJC-1BcrpSaponinABCIC50FITCMDRH2DCFH-DAEGFRMMPM.P.50% inhibitory concentration5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodideDMSOP-glycoproteinROSCell cycle distributionDimethylsulfoxideCytotoxicityFerroptosisMultidrug resistanceMelting pointMitochondrial membrane potentialbreast cancer resistance proteinPropidium iodideATP-binding cassetteReactive oxygen speciesEpidermal growth factor receptor
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Authors
Armelle T. Mbaveng, Blanche L. Ndontsa, Victor Kuete, Yves M.M. Nguekeu, İlhami Ãelik, Roukayatou Mbouangouere, Pierre Tane, Thomas Efferth,