Plasma pharmacokinetics and cerebral nuclei distribution of major constituents of Psoraleae fructus in rats after oral administration

Article ID	Journal	Published Year	Pages	File Type
8518652	Phytomedicine	2018	9 Pages	PDF

Keywords

tmax CMC-Na ACN PFE EtOAc ESI+MRT RSD Q-Trap Precursor ion MRM ESI LLOQ TIC Aβ42 Cmax AUC LC-MS/MS LC–MS/MS S/N t1/2 β-amyloid 42 Ethyl acetate internal standard Acetonitrile Formic acid relative standard deviation standard deviation collision energy lower limit of quantification maximum drug concentration CNS LLOD Retention time central nervous system Mass spectrometry Pharmacokinetics Methanol lower limit of detection area under curve MeOH Signal-to-noise ratio multiple reaction monitoring elimination half-life Molecular weight declustering potential Prenylflavonoids Carboxymethyl cellulose sodium quality control Coumarins Product ion electrospray ionization

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Plasma pharmacokinetics and cerebral nuclei distribution of major constituents of Psoraleae fructus in rats after oral administration

Authors

Yan-Fang Yang, You-Bo Zhang, Zhi-Jing Chen, Ying-Tao Zhang, Xiu-Wei Yang,