Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8523143 | Antiviral Research | 2018 | 43 Pages |
Abstract
Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic fever/dengue shock syndrome. At present, no antiviral drugs are available for treatment DENV infections. In this study, a screening system based on a DENV-infected cell-based assay identified a novel anti-DENV agent with a benzimidazole skeleton, named Compound-B, which demonstrated antiviral activity specific to four DENV serotypes (EC50: 1.32-4.12 μM). Analysis of a single amino acid substitution of Compound-B-resistant DENV2 revealed that mutation C87S in the non-structural protein 4A (NS4A) contributes to resistance to Compound-B.
Keywords
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Authors
Haruaki Nobori, Shinsuke Toba, Ryu Yoshida, William W. Hall, Yasuko Orba, Hirofumi Sawa, Akihiko Sato,