Emerging role of lncRNAs in systemic lupus erythematosus

Article ID	Journal	Published Year	Pages	File Type
8524581	Biomedicine & Pharmacotherapy	2018	9 Pages	PDF

Abstract

Long non-coding RNAs (lncRNAs), defined as â¥200 base pairs in length but have little translation potential, play a key role in imprinting control, immune cell differentiation, apoptosis and immune responses. Recently, many potential lncRNAs have been revealed to contribute to a new layer of molecular regulation of systemic lupus erythematosus (SLE). Immune-related functional lncRNAs may serve as novel therapeutic targets and disease biomarkers to provide potential support for clinic treatment in this disease. In this review, we will briefly introduce the identification, biogenesis and functions of lncRNAs, and summarize recent advance in the role of lncRNAs in SLE.

Keywords

RNAP lncRNAs ncRNAs ERα T1DM Tregs TUG1 EZH2 DNA methyltransferases RORγt DNMTs ILCs NEAT1 GAS5 XIST lincRNAs TNF NURF X inactive specific transcript Ddx5 DCs DBD NFAT miRNAs SSC dhfr hnRNPs MAPK Long non-coding RNAs non-coding RNAs RNA polymerase Rheumatoid arthritis systemic sclerosis interleukin enhancer of zeste homolog 2 autoimmunity DNA-Binding Domain dihydrofolate reductase type 1 diabetes mellitus metastasis associated lung adenocarcinoma transcript 1 Heterogeneous nuclear ribonucleoproteins microRNAs Dendritic cells Innate lymphoid cells Regulatory T cells Primary sjögren’s syndrome Nuclear Factor of Activated T Cells Immune function tumor necrosis factor Nest Systemic lupus erythematosus SLE MALAT1 Genome-wide association studies GWAS complement 3 lupus nephritis HOTAIR mitogen-activated protein kinase Estrogen receptor α