Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8524654 | Biomedicine & Pharmacotherapy | 2018 | 12 Pages |
Abstract
The widespread use of plants as accessible anticancer agents leads to the identification of many natural source chemotherapeutic agents. Scutellaria one of the popular genus of flowering plants has been used for various human illnesses for thousands of years. Scutellaria has anti-metastatic, anti-proliferative, anti-invasion, anti-angiogenic and apoptosis effects in vitro as well as in vivo. Despite numerous reports on the cytotoxic-antitumor activity of the plant, there are still some issues need further consideration. Issues such as unjustified interpretations, lack of attention to the pharmacokinetics profile and weak study design may affect the final decision about the use of plants as anticancer agents and possibly needs reconsideration. In this review, we have summarized the potential health benefits of Scutellaria and its active components also the underlying mechanism of cytotoxicity and antitumor activity. Meanwhile we have discussed concerns may interfere with the precise conclusion.
Keywords
Bcl-2STAT3ERαHIF-1αUCP2FOXO3IGF-1IL6ADRiNOSuPATCMuPARFOXM1ERKRhoAmTORRUNX3UVBNrf2ScutellariaTGF-β1NPMMMP-2 and MMP-9American Depositary Receipt5-FUForkhead box protein O3MAPKAnti-angiogenicultraviolet Binterleukin 6SCLCtransforming growth factor beta 1EMTforkhead box M1ApoptosisShhNSCLCSmall cell lung cancerNon-small cell lung cancerinducible nitric oxide synthaseextracellular signal regulated kinasesendoplasmic reticulumsonic hedgehogAnti-proliferativeAnti-invasiontraditional Chinese medicinehypoxia-inducible factor 1-alphainsulin-like growth factor 1phosphatase and tensin homolog5-fluorouracilB-cell lymphoma 2Acute megakaryoblastic leukemiasignal transducer and activator of transcription 3Matrix metalloproteinasesMethyl ethyl ketoneMEKnucleophosminMechanistic target of rapamycinHuman papillomavirusHPVuncoupling protein 2mitogen-activated protein kinasePtenCRCEpithelial–mesenchymal transitionEstrogen receptor alpha
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Authors
Samira EghbaliFeriz, Akram Taleghani, Zahra Tayarani-Najaran,