| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8524668 | Biomedicine & Pharmacotherapy | 2018 | 9 Pages |
Abstract
The present study showed that HIF-1 modulated Cyclin D1 expression might through shaping a positive loop with AKT proteins. Additionally, HIF-1α promoted the tumor cells growth, migration and invasion in osteosarcoma through the activation of the AKT/Cyclin D1 signal cascade. We proposed that HIF-1 could be served as a marker for distinguishing osteosarcoma and an effective therapeutic target for osteosarcoma.
Keywords
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Authors
Bo Zhang, Ya-Li Li, Jin-Long Zhao, Zhen Ouyang, Chao Yu, Bin-Hui Yang, Xiao-Rui Yu,