Silymarin prevents apoptosis through inhibiting the Bax/caspase-3 expression and suppresses toll like receptor-4 pathway in the SNc of 6-OHDA intoxicated rats

Article ID	Journal	Published Year	Pages	File Type
8524817	Biomedicine & Pharmacotherapy	2018	10 Pages	PDF

Keywords

MPA NADPH GSH GPX SNC Bcl2 GSSG PVDF MDA i.p.NSAIDS LPS ECL PBS TLR MPTP 6-OHDA NF-κB Bcl-2–associated X protein 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-Hydroxy dopamine MPO ROS Hydrogen peroxide EDTA Ethylenediaminetetraacetic acid Metaphosphoric acid SDS-PAGE interleukin Bax enhanced chemiluminescence triethanolamine Enzyme-linked immunosorbent assay ELISA toll like receptor Oxidative stress substantia nigra pars compacta Neurodegeneration TUNEL Team Apoptosis standard error of mean intraperitoneal Non-steroidal anti-inflammatory drugs CNS Dopaminergic Lesion SOD Superoxide dismutase central nervous system Silymarin TNF-α nuclear factor kappa B B-cell lymphoma 2 lipopolysaccharide malondialdehyde Phosphate-buffered saline SEM myeloperoxidase nicotinamide adenine dinucleotide phosphate H2O2 Poly ethylene glycol PEG reduced glutathione caspase glutathione reductase glutathione peroxidase Reactive oxygen species

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Silymarin prevents apoptosis through inhibiting the Bax/caspase-3 expression and suppresses toll like receptor-4 pathway in the SNc of 6-OHDA intoxicated rats

Authors

Rasool Haddadi, Alireza Mohajjel Nayebi, Shahla Eyvari Brooshghalan,