Tumor-derived extracellular vesicles in angiogenesis

Article ID	Journal	Published Year	Pages	File Type
8525124	Biomedicine & Pharmacotherapy	2018	6 Pages	PDF

Abstract

Angiogenesis is crucial for tumor growth and metastasis. Recent studies revealed that tumor cells promote angiogenesis by secreting extracellular vesicles, which can be captured by endothelial cells. These tumor-derived extracellular vesicles carry microRNAs, long non-coding RNAs, and proteins, which activate pro-angiogenic signaling in endothelial cells. In this review, we will summarize the roles of tumor-derived extracellular vesicles in angiogenesis and the underlying molecular mechanisms.

Keywords

Microvesicles MVBS PML PHD1 eNOS HIF-1α lncRNAs pAkt PTP1B Phosphorylated protein kinase B FOXM1 ILVs ccRCC PHD2 JAK-STAT pVHL MLC MLCK MVS ADP-ribosylation factor 6 miRs ARF6 MMP-9 AMPK PDGF-β NF-κB PLD IL-6 Von hippel-lindau protein EFNA3 bFGF ERK AMP-activated protein kinase ECs HCC Long non-coding RNAs intraluminal vesicles Angiogenesis Akt interleukin-6 multivesicular bodies forkhead box M1 Extracellular vesicles FIH-1 PhDs Metastasis-associated lung adenocarcinoma transcript 1 microRNAs blood brain barrier BBB NSCLC Non-small cell lung cancer Clear cell renal cell carcinoma Endothelial cells endothelial nitric oxide synthase hypoxia-inducible factor-1α platelet-derived growth factor-β Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Phospholipase D Promyelocytic leukemia Matrix metalloproteinase-9 MALAT1 Multiple myeloma Phosphatase and tensin homologue protein kinase B Prolyl hydroxylase prolyl hydroxylases Pten Hepatocellular carcinoma extracellular signal-regulated kinase Myosin light-chain kinase