Involvement of the NO/sGC/cGMP/K+ channels pathway in vascular relaxation evoked by two non-quinazoline Î±1-adrenoceptor antagonists

Article ID	Journal	Published Year	Pages	File Type
8525131	Biomedicine & Pharmacotherapy	2018	10 Pages	PDF

Keywords

Gli PKC tetraethylammonium chloride IbTX PLC IP3 4-AP pKa iberiotoxin PKG SGC eNOS cGMP ODQ EDHF HASMC PGI2 COX IBMX α1-adrenoceptor antagonists 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one K+ channels l-NAME Nω-nitro-l-arginine methyl ester adenylyl cyclase l-arginine cyclooxygenase l-Arg endothelial NO synthase Endothelium HAEC Soluble guanylyl cyclase diacylglycerol DAG human aortic smooth muscle cells human aortic endothelial cells Endothelium-derived hyperpolarizing factor phospholipase C Nitric oxide Benign prostatic hyperplasia BPH cAMP-dependent protein kinase A Protein kinase C prostacyclin TEA glibenclamide

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Involvement of the NO/sGC/cGMP/K+ channels pathway in vascular relaxation evoked by two non-quinazoline Î±1-adrenoceptor antagonists

Authors

Monika Kubacka, Magdalena KotaÅska, Grzegorz Kazek, Anna Maria Waszkielewicz, Henryk Marona, Barbara Filipek, Szczepan Mogilski,