Effects of amlodipine and valsartan on glibenclamide-treated streptozotocin-induced diabetic rats

Untreated diabetic rats had 100% mortality before 6 weeks but addition of valsartan to glibenclamide improved survival rate (71.4% compared with 57.4% in glibenclamide-treated) and blood glucose control but this was not so with glibenclamide plus amlodipine-treated group with 50% survival rate. Treatment ameliorated pathologic changes and there was histologic evidence of organ protection among the various treatment groups when compared with the untreated diabetic group. Addition of valsartan to glibenclamide improved treatment outcome compared to when glibenclamide was used alone but this was not so with the addition of amlodipine to glibenclamide.