Blood-brain barrier permeability and neuroprotective effects of three main alkaloids from the fruits of Euodia rutaecarpa with MDCK-pHaMDR cell monolayer and PC12 cell line

Article ID	Journal	Published Year	Pages	File Type
8525902	Biomedicine & Pharmacotherapy	2018	6 Pages	PDF

Keywords

TCM ACN HBSS EDM RSD TEER P-gp FBS Rutaecarpine 1-methyl-4-phenylpyridinium ion DMEM Dehydroevodiamine RCP 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide DMSO Dulbecco's modified Eagle's medium MPP+MTT P-glycoprotein Hydrogen peroxide Alkaloids Acetonitrile relative standard deviation evodiamine Hank's balanced salts solution CNS Dimethylsulfoxide BBB fetal bovine serum central nervous system apparent permeability coefficients traditional Chinese medicine Blood-brain barrier Methanol Neuroprotection transepithelial electrical resistance MeOH Permeability H2O2 Papp optical density high performance liquid chromatography HPLC quality control

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Blood-brain barrier permeability and neuroprotective effects of three main alkaloids from the fruits of Euodia rutaecarpa with MDCK-pHaMDR cell monolayer and PC12 cell line

Authors

Yi-Nan Zhang, Yan-Fang Yang, Xiu-Wei Yang,