Curcumin and endometriosis: Review on potential roles and molecular mechanisms

Article ID	Journal	Published Year	Pages	File Type
8525925	Biomedicine & Pharmacotherapy	2018	7 Pages	PDF

Abstract

Turmeric, an important spice all around the world, is obtained from the rhizomes of Curcuma longa, a member of the Zingiberaceae family. It has been used in the prevention and treatment of many diseases since ancient times. Curcumin is the principal polyphenol isolated from turmeric. Several evidences have shown the anti-inflammatory, antioxidant, anti-tumor, anti-angiogenesis, and anti-metastatic activities of curcumin. In this review, relevant articles on the effect of curcumin on endometriosis and possible molecular mechanisms are discussed.

Keywords

B cell lymphoma-2 FGF Bcl-2 TAC HUVEC CCl4 MDA IGF-1 Nrf2-Keap1 IFN-γ AP-1 MCP-1 HIF-1α PDGF Iκ-B IL-8 MVD ELAM-1 VCAM-1 HGF HER-2 TIMP-2 ICAM-1 COX-2 NF-κB MMP EGF IL-6 PBMC TGF-β GPX GnRH ROS Endometriosis insulin-like growth factor-1 interferon-γ Interleukin-8 interleukin-6 Bax transforming growth factor-β Microvessel density tumor necrosis factor-α Immune system Turmeric Human umbilical vein endothelial cells peripheral blood mononuclear cells cyclooxigenase-2 Total antioxidant capacity hypoxia-inducible factor-1α epidermal growth factor Hepatocyte growth factor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)platelet derived growth factor fibroblast growth factor TNF-α nuclear factor-κB matrix metalloproteinase malonaldehyde membrane type 1 matrix metalloproteinase inhibitor of kappa B intracellular adhesion molecule-1 vascular cell adhesion molecule-1 endothelial leukocyte adhesion molecule-1 gonadotropin releasing hormone human papilloma viruses HPV Bcl-2-associated X protein monocyte chemoattractant protein-1 activator protein-1 Polyphenol Carbon tetrachloride Curcumin glutathione peroxidase Reactive oxygen species Human epidermal growth factor receptor-2