| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8526100 | Biomedicine & Pharmacotherapy | 2018 | 8 Pages |
Abstract
We aimed to review methylation status of key genes involved in hematopoietic malignancies such as IKZF1, CDKN2B, TET2, CYP1B1, SALL4, DLC1, DLX family, TP73, PTPN6, and CDKN1C; and their significance in pathogenesis of ALL. The DNA methylation alterations in promoter regions of the genes have been shown to play crucial roles in tumorigenesis. Methylation -based inactivation of these genes has also been reported as associated with prognosis in acute leukemia. In this review, we also addressed the association of gene expression and methylation pattern in ALL patients.
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Authors
Mina Rahmani, Mehdi Talebi, Majid Farshdousti Hagh, Abbas A.Hosseinpour Feizi, Saeed Solali,