An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds

Article ID	Journal	Published Year	Pages	File Type
8526141	Biomedicine & Pharmacotherapy	2018	15 Pages	PDF

Abstract

Our results clearly disclose the specific antioxidant activity of these natural compounds and their ability to increase SIRT1 expression and AMPK activation.

Keywords

HRP KMBA tween-Tris buffered saline TOSC T-TBS SIN-1 sirtuin 1 NAMPT PMSF CCl4 GSSG AMPK mTOR GSH PVDF DTPA FBS Sirt1 SDS DMEM PBS BSA DMSO Dulbecco's modified Eagle's medium NAD+ROS bovine serum albumin Antioxidants Berberine Oxidative stress Diethylenetriaminepentaacetic acid polyvinylidene difluoride Dimethyl sulfoxide RONS sodium dodecyl sulfate fetal bovine serum Phosphate buffered saline nicotinamide adenine dinucleotide nicotinamide phosphoribosyl transferase Mechanistic target of rapamycin adenosine monophosphate-activated protein kinase Polyphenols reduced glutathione Carbon tetrachloride oxidised glutathione Reactive oxygen and nitrogen species Reactive oxygen species

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An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds

Authors

Jonathan Fusi, Sara Bianchi, Simona Daniele, Silvia Pellegrini, Claudia Martini, Fabio Galetta, Luca Giovannini, Ferdinando Franzoni,