Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8527235 | Chinese Journal of Natural Medicines | 2017 | 6 Pages |
Abstract
Two new steroidal alkaloids, isoconkuressine and N-formylconessimine, together with 6 known steroidal alkaloids including conkuressine, conessine, isoconessimine, conimine, conarrhimine, and funtudienine, were isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Their intrinsic antibacterial activities and synergistic effects with penicillin and vancomycin were analyzed in methicillin sensitive staphylococcus aureus (MSSA) and methicillin resistant staphylococcus aureus (MRSA). Two of the steroidal alkaloids including one new compound (N-formylconessimine) showed potential antibacterial activity and possessed synergistic effects with penicillin and vancomycin, respectively.
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Authors
Li-Na ZHOU, Xiao-Lei GE, Ting-Ting DONG, Hui-Yuan GAO, Bo-Hang SUN,