Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8527303 | Chinese Journal of Natural Medicines | 2017 | 4 Pages |
Abstract
The present study was designed to investigate the chemical constituents of the roots of Cyathula officinalis. Compounds were isolated by silica gel, Sephadex LH-20, ODS column chromatography, and preparative HPLC. Their structures were determined on the basis of 1D and 2D NMR techniques, mass spectrometry, and chemical methods. One new oleanane-type triterpenoid saponin, 28-O-[α-L-rhamnopyranosyl-(1â3)-β-D-glucuronopyranosyl-(1â3)-β-D-glucopyranosyl] hederagenin (1), was isolated from the roots of Cyathula officinalis. The anti-inflammatory activities of the isolates were evaluated for their inhibitory effects against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages cells. Compounds 2, 4, and 6 exhibited moderate anti-inflammatory activities.
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Authors
Yun-Tao JIANG, Wen-Jing YAN, Chu-Lu QI, Ji-Qin HOU, Yan-Ying ZHONG, Hui-Jun LI, Hao WANG, Ping LI,