Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8528878 | European Journal of Pharmacology | 2018 | 27 Pages |
Abstract
Diet-induced obesity (DIO) is commonly associated with hyperleptinemia and leptin resistance. Leptin acts centrally to inhibit food intake and increase energy expenditure, thereby preventing body weight gain. Resistance to the biological effects of leptin represents a major obstacle in utilizing exogenously administered leptin as a treatment option for obesity. Of importance, recent studies demonstrate that naturally occurring compounds improve leptin sensitivity in DIO mice, as revealed by anorectic and body weight-lowering effects. To date, the role of sulforaphane (SFN, an isothiocyanate derived from cruciferous vegetables) on leptin responsiveness has not been examined, in spite of its known beneficial effects toward lowering body weight gain in DIO. In the present study, we determined the extent to which SFN regulates leptin responsiveness in high-fat high-sucrose (HFHS) diet-fed obese mice. SFN treatment (0.5â¯mg/kg/day, s.c.) for 23 days in HFHS-fed mice improved the responsiveness to intraperitoneally-injected leptin by promoting significant decreases in cumulative food intake and body weight gain. A single leptin injection (2â¯mg/kg; i.p.) resulted in significant decreases in food intake at 24â¯h and 38â¯h time points. In addition, a triple leptin injection (1â¯mg/kg/day, 3 days; i.p.) led to significant decreases in food intake at 14â¯h, 24â¯h, 38â¯h, 48â¯h, and 62â¯h time points. Furthermore, single and triple leptin injections prevented body weight gain at 38â¯h and 62â¯h time points, respectively. The present findings suggest that intervention with SFN, a naturally occurring isothiocyanate, has the potential to improve leptin responsiveness in DIO.
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Authors
Noha M. Shawky, Lakshman Segar,