Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8528958 | European Journal of Pharmacology | 2018 | 28 Pages |
Abstract
The purpose of the present study was to investigate whether É-tocopherol exhibited neuro-protective effects in chronic unpredictable mild stress (CUMS) mice through the regulation of autophagy. Deficits in behavioural tests, including a sucrose preference test, open field test, forced swim test, and tail suspension test, were ameliorated following É-tocopherol administration. To study the potential mechanism, western blots were performed on both prefrontal cortex and hippocampus samples. Similar to the degree of autophagy, the activities of adenosine monophosphate-activated protein kinase (AMPK) and Unci-51 like autophagy activating kinase-1 (ULK1) were decreased after CUMS stimulation. In addition, we also found increased activity of the mammalian target of rapamycin (mTOR), which was significantly affected following administration of É-tocopherol, as well as its three downstream pathways. Taken together, our study found that É-tocopherol might potentially promote autophagy to induce anti-depressive responses in CUMS mice though the AMPK/mTOR pathway.
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Cellular and Molecular Neuroscience
Authors
Xiaoyan Huang, Haoran Wu, Ruizhi Jiang, Guangda Sun, Jiali Shen, Mengling Ma, Chuanhui Ma, Shijia Zhang, Zhiheng Huang, Qinan Wu, Gang Chen, Weiwei Tao,