Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8529075 | European Journal of Pharmacology | 2018 | 36 Pages |
Abstract
We found that, in this model of AD, 7,8-DHF treatment decreased cortical Aβ plaque deposition and protected cortical neurons against reduced dendritic arbor complexity but had no significant impact on the density of dendritic spines. In addition 7,8-DHF treatment protected against hippocampal increase in the level of choline-containing compounds and glutamate loss, but had no significant impact on hippocampal neurogenesis.
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Authors
Nurgul Aytan, Ji-Kyung Choi, Isabel Carreras, Leah Crabtree, Brian Nguyen, Margaret Lehar, Jan Krzysztof Blusztajn, Bruce G. Jenkins, Alpaslan Dedeoglu,