Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8530049 | European Journal of Pharmacology | 2017 | 8 Pages |
Abstract
Simvastatin induces subclinical mitochondrial dysfunction in healthy subjects, which can be partly reversed by treatment with ubiquinol. This model of pharmacologically induced and reversed mitochondrial dysfunction can be used to study the effects of compounds that enhance mitochondrial function in healthy subjects.
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Authors
Marcus P.J. van Diemen, Cécile L. Berends, Naila Akram, Joep Wezel, Wouter M. Teeuwisse, Bert G. Mik, Hermien E. Kan, Andrew Webb, Jan Willem M. Beenakker, Geert Jan Groeneveld,