The impact of metabolic reprogramming on dendritic cell function

Article ID	Journal	Published Year	Pages	File Type
8530863	International Immunopharmacology	2018	10 Pages	PDF

Abstract

Dendritic cells (DCs) are antigen-presenting cells with the ability to activate naïve T cells and direct the adaptive cellular immune response toward a specific profile. This is important, as different pathogens demand specific “profiles” of immune responses for their elimination. Such a goal is achieved depending on the maturation/activation status of DCs by the time of antigen presentation to T cells. Notwithstanding this, recent studies have shown that DCs alter their metabolic program to accommodate the functional changes in gene expression and protein synthesis that follow antigen recognition. In this review, we aim to summarize the data in the literature regarding the metabolic pathways involved with DC phenotypes and their functions.

Keywords

APC mTORC1 T2DM Nrf2 NADPH OXPHOS sirtuin 1 mTOR COX-2 PAMPs CCR7 NF-kB PPARγ shRNA PFKFB GLUT EAE PRR TLR GM-CSF GSK3 PGC-1α ILT ATG7 autophagy-related gene 7 BMDC AMPK Sirt1 E-FABP mTORC2 HIF1α AICAR RAPA 5-aminoimidazole-4-carboxamide ribonucleotide LPS mDCs PBMC CTL HDL NKT α-GalCer DAMPs peroxisome proliferator-activated receptor gamma coactivator 1-alpha atRA PI3K/AKT short interfering RNA short hairpin RNA siRNA Adenosine Triphosphate ATP all-trans retinoic acid antigen-presenting cell experimental autoimmune encephalomyelitis Autophagy docosahexaenoic acid Fatty acid pathogen-associated molecular patterns interleukin toll like receptor tumor necrosis factor-alpha Glucose transporter cluster of differentiation DHA Type 2 diabetes mellitus RALDH Rapamycin Retinaldehyde dehydrogenase immunoglobulin-like transcript natural killer T cell Dendritic cell iNKT cells peripheral blood mononuclear cells Dendritic cells Bone marrow-derived dendritic cells Monocyte-derived dendritic cells myeloid dendritic cells Age Cyclooxygenase-2 endoplasmic reticulum hypoxia inducible factor 1 alpha granulocyte-macrophage colony-stimulating factor invariant natural killer T TNF-α nuclear factor kappa B Oxidative phosphorylation cytotoxic T lymphocyte high density lipoprotein low density lipoprotein LDL lipopolysaccharide Metabolism Advanced glycation end products damage-associated molecular pattern molecules 5′ adenosine monophosphate-activated protein kinase Peroxisome proliferator-activated receptor gamma Glucose glyceraldehyde-3-phosphate dehydrogenase glycogen synthase kinase 3 pattern recognition receptors