| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8531129 | International Immunopharmacology | 2018 | 11 Pages |
Abstract
The modified model of ovalbumin (OVA)-induced chronic asthma overwhelming the allergen offered immune tolerance as BALF inflammatory cells were persisted during the progression of disease when compared to conventional model (a and b). Persistent airway inflammation in the modified model was accompanied by a marked increase in expression of Th2 cytokines, inflammatory cells infiltration, mucus production, and collagen deposition in lung tissues. Similar to asthma patients, our modified model also imitates steroid-refractory remodeling traits (c). Overall, mice underwent modified protocol may be a useful tool to test the potential of anti-asthmatic drugs, prior to their clinical trials.79
Keywords
ASMSignal transducer and activator of transcription proteinTGF-βMucin 5ACType 2 helper T cellsSTAT-6Th2collagen, type I, alpha 1Col1α1MUC5ACMODOVAMMP-9PBSα-SMAcDNAComplementary DNAH&EChronic asthmaRNAribonucleic acidperiodic acid-SchiffAirway inflammationOvalbuminα-smooth muscle actininterleukinconAirway remodelingBALFTransforming Growth Factor Betaanalysis of varianceANOVAimmune toleranceMasson's trichromestandard error of meanDexamethasoneAirway smooth muscleMatrix metalloproteinase-9Bronchoalveolar lavage fluidPhosphate-buffered salineSEMPASHematoxylin and Eosinpolymerase chain reactionPCR
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Authors
Gurupreet S. Sethi, Amarjit S. Naura,