| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8531613 | International Immunopharmacology | 2018 | 10 Pages |
Abstract
Schematic presentation of proposed mechanism of SYK inhibition mediated lung protection. β-Glucan acts through dectin-1 receptor activating tyrosine kinase (SYK) to further activate inflammasome components, causing inflammation. Inflammatory cytokines release IL-1β and recruit Th17 and neutrophils, causing lung damage. MNS, a potent SYK inhibitor, reduces lung damage via decreased Th17 and neutrophil expression. Meanwhile, the Treg population is increased through antigen-presenting cells by their cytokine milieu.207
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Authors
Divyesh Patel, Sagar Gaikwad, Naveen Challagundla, Manish Nivsarkar, Reena Agrawal-Rajput,