C-type natriuretic peptide (CNP) in endothelial cells attenuates hepatic fibrosis and inflammation in non-alcoholic steatohepatitis

Article ID	Journal	Published Year	Pages	File Type
8534580	Life Sciences	2018	37 Pages	PDF

Abstract

The overexpression of CNP in endothelial cells has anti-fibrotic and anti-inflammatory effects in liver during HFD-induced NASH in mice.

Keywords

HSC TGF-β CDAA NAFL NEFA TIMP-1 CNP STD IL-1β MCP-1 HFD GTT α-SMA ALT IL-6 MMP-9 LSEC insulin tolerance test AST Alanine aminotransferase Non-alcoholic steatohepatitis Non-esterified fatty acid α-smooth muscle actin ITT transforming growth factor-β Transgenic aspartate transaminase glucose tolerance test tumor necrosis factor-α standard diet high-fat diet liver sinusoidal endothelial cell Hepatic stellate cell Endothelial cells TNF-α Nash monocyte chemoattractant protein-1 C-type natriuretic peptide Non-alcoholic fatty liver

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C-type natriuretic peptide (CNP) in endothelial cells attenuates hepatic fibrosis and inflammation in non-alcoholic steatohepatitis

Authors

Cho-Rong Bae, Jun Hino, Hiroshi Hosoda, Mikiya Miyazato, Kenji Kangawa,