Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis

Article ID	Journal	Published Year	Pages	File Type
8534632	Life Sciences	2018	11 Pages	PDF

Abstract

Illustrated diagram explores the potential protective effects of DS and PTX against cholestatic liver cirrhosis.142

Keywords

NF-κB TGF-β MDA NRF-2 MTC HYP PTX eNOS BDL iNOS GSH H&E ROS transforming growth factor-beta Masson's trichrome Diosmin SOD inducible nitric oxide synthase endothelial nitric oxide synthase Superoxide dismutase cytoglobin Nuclear factor erythroid 2–related factor 2 nuclear factor kappa-light-chain-enhancer of activated B cells Keap-1 malondialdehyde Hematoxylin and Eosin hydroxyproline Kelch-like ECH-associated protein 1 p38 mitogen activated protein kinase Pentoxifylline bile duct ligation reduced glutathione Reactive oxygen species

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Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis

Authors

Fares E.M. Ali, Adel G. Bakr, Amira M. Abo-youssef, Amany A. Azouz, Ramadan A.M. Hemeida,