| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8534857 | Life Sciences | 2018 | 6 Pages |
Abstract
Summarizing, data here reported demonstrate that inhibition of HO-1 enhances rat liver regeneration after PH which is associated to a very rapid increase in the levels of inflammatory mediators such as IL-6, phopsho-JNK and phospho-STAT3, suggesting that HO-1 could act as a negative modulator of liver regeneration. Knowledge about the mechanisms of liver regeneration can be applied to clinical problems caused by delayed liver growth, and HO-1 repression may be a mechanism by which cells can faster proliferate in response to tissue damage.
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Authors
Monica Pibiri, Vera Piera Leoni, Luigi Atzori,